Klotho (alphaKlothoLR) (20mcg)

Product Description
alphaKlothoLR is a patented, long-release version of the recombinant Klotho protein, which contains specific amino acid sequences, linkers, and an albumin binding group that allows for a sustained delivery of Klotho with cellular activity up to 19 days.

This research-grade construct combines α-Klotho protein with a proprietary 29-amino acid albumin binding peptide (GGSGGSGGSGGRLIEDICLPRWGCLWEDD). The modification enables strong albumin binding affinity (<20 nM) while maintaining native FGF23 binding activity (15-30 nM). Produced through recombinant expression with rigorous third-party testing. Each batch includes HPLC and LC-MS verification to confirm molecular identity and purity standards. Complete analytical documentation supports laboratory applications investigating protein-albumin interactions, FGF23 signaling pathways, and albumin binding mechanisms. For in vitro research use only. Klotho Protein Information Property Value Peptide Sequence α-Klotho protein (1012 amino acids) + albumin binding construct: GGSGGSGGSGGRLIEDICLPRWGCLWEDD Molecular Weight ~133-135 kDa (full construct with albumin binder) Albumin Binding Affinity (Kd) <20 nM FGF23 Binding Affinity (Kd) 15-30 nM (optimized: 16.2 nM) Synonyms α-Klotho-albumin binding construct, Modified Klotho with glycine-serine linker Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process. Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug. 99%+ Purity, Third Party Tested Independently verified by three separate certified laboratories. COAs available pre-purchase. GMP Manufacturing Standards Synthesized in USA-registered facilities following Good Manufacturing Practices. Full chain of custody documentation. Best In Class Fulfillment Same-day shipping on orders before 12 PM PT. Free standard domestic shipping on orders over $400. Zero Fillers or Additives Pure active compounds only. Independently verified composition for reliable in vitro studies. Scientific Reviewer Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations. Disclaimer: For Research Purposes Only This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.